10,768.05-45.4
Stock Analysis, IPO, Mutual Funds, Bonds & More

Recovered patients generated antibodies that can neutralise coronavirus

Some antibodies are blocking the virus from entering the cells.

PTI|
Last Updated: May 28, 2020, 06.04 PM IST
0Comments
iStock
coronavirus-vaccine-antibodies1_iStock
The researchers identified three distinct antibodies that were shown to be the most potent of the bunch in neutralising the virus.
WASHINGTON: A study of 149 people who recovered from COVID-19 shows that most individuals had generated at least some antibodies that were intrinsically capable of neutralising the SARS-CoV-2 virus, scientists say, a finding that may help develop a universal vaccine for the disease.

The first results from an immunological study of these patients by researchers from Rockefellar University in the US also found that the amount of antibodies generated varied widely.

Antibodies vary widely in their efficacy. While many may latch on to the virus, only some are truly "neutralising" meaning that they actually block the virus from entering the cells, the researchers noted.

The scientists collecting blood samples from volunteers who have recovered from COVID-19, according to the findings shared on pre-print server BioRxiv ahead of submission to peer-reviewed scientific journals.

The majority of the samples they studied showed poor to modest "neutralising activity," indicating a weak antibody response, the researchers said.

However, a closer look revealed everyone's immune system is capable of generating effective antibodies -- just not necessarily enough of them, they said.

Even when neutralising antibodies were not present in an individual's serum in large quantities, researchers could find some rare immune cells that make them.

iStock
coronavirus-vaccine-antibodies_iStock
A closer look revealed everyone's immune system is capable of generating effective antibodies -- just not necessarily enough of them

"This suggests just about everybody can do this, which is very good news for vaccines," said Michel C. Nussenzweig from Rockefeller University.

"It means if you were able to create a vaccine that elicits these particular antibodies, then the vaccine is likely to be effective and work for a lot of people," Nussenzweig said.

Moreover, the researchers identified three distinct antibodies that were shown to be the most potent of the bunch in neutralising the virus.

They are working to develop them further into therapeutic and preventive drugs.

From the beginning of April and over 5 weeks, 149 people who had recovered from COVID-19 visited The Rockefeller Hospital to donate plasma, the portion of the blood that contains the antibodies, and the immune B-cells that produce them.

The participants had experienced symptoms for an average of 12 days, and had their first symptoms on average 39 days before plasma donation.

The team used an essay they had developed to test the neutralising activity of the plasma samples.

This involved mixing the plasma with a pseudo SARS-CoV-2 virus and measuring how well this mixture could still infect human cells in a dish.

From Boris Johnson, Karim Sisters To Bond Girl Olga, And Andy Cohen: Celebs Who Tested Posi...

of 19
Next
Prev
Play Slideshow

COVID-19: The Great Leveller

18 Mar, 2020
The coronavirus outbreak has brought the world to a standstill. With deserted streets, empty parks and most of the people self-quarantined, it seems that the planet is taking a break. In many ways, COVID-19 has been a great leveller of sorts. Be it the rich, the poor or even the famous, the virus has affected people from all walks of life and spared none.Ever since COVID-19 was declared a pandemic by the World Health Organization, several celebrities - actors, singers and politicians - across the world have been diagnosed with the infectious disease. Many of them took to social media to share updates about their health with fans.We have prepared a comprehensive list of all the famous personalities who have been diagnosed with the novel coronavirus.
Next

Also Read

Fighting the Coronavirus with innovative tech

View: How Coronavirus accentuates inequality

Targets for coronavirus vaccine identified by scientists

Australia cuts citizen returns as coronavirus cases rise

A new world order for the coronavirus era is emerging

Global coronavirus cases surge past 12 million

Comments
Add Your Comments
Commenting feature is disabled in your country/region.

Popular Categories


Other useful Links


Copyright © 2020 Bennett, Coleman & Co. Ltd. All rights reserved. For reprint rights: Times Syndication Service